P-183: A Low Risk Approach for Treatment of Infertile PCOS Patients

Background: Ovarian hyperstimulation syndrome is one of the most common complications of infertility treatment. As the fluid-filled egg follicles begin to grow within the ovary, the ovary enlarges. Sometimes, that fluid can cause fluid elsewhere in the body to shift into the abdominal cavity or the lungs. Women with PCOS are at a greater risk for developing OHSS due to the already large number of follicles on the ovary and the tendency for women with PCOS to over-respond to the hormones. The purpose of this study was decreased OHSS due to induction of ovulation with clomiphene citrate and then letrozole. Materials and Methods: This is prospective clinical research from Dr.Rasekh clinic. 36 infertile polycystic ovarian syndrome women were selected with 47 months infertility. The average age of them is 27.3 years (STD=5). The 36patients (40%) with drug regimen; initially tab clomiphene citrare (from day 3 of menstrual cycle).Then the second drug Letrozole was started from day 8 to 11 menstrual cycle. OHSS was 0%. Pregnancy rate was 8 (22%). The patients were monitored for ovulation by translational ultrasonography, with measurement of number and size of the follicles, as well as endometrial thickness. Human chorionic gonadotrophin (HCG) was injected intramuscularly when at least one mature follicle >18 mm diameter was detected. Data was analyzed with SPSS software. Results: The rate of OHSS is at minimum in this method (p<0.05). This means that can be completely prevented the creation of OHSS. Pregnancy rate is almost considered desirable (p<0.05). Conclusion: We suggest that this method will be employed for the prevention of OHSS that is a serious complication in treatment of infertile women .Whilst this method has been favorite fertility rate. Another feature of this method is its low cost.